While minimal-rely MBL seldom progresses to CLL, large-depend MBL progresses to CLL demanding therapy in a fee of 1% to 2% every year. Substantial-rely MBL is distinguished from Rai 0 CLL based upon whether or not the B-cell depend is earlier mentioned or under five × 109/L. Even though men and women with each superior-depend MBL and CLL Rai stage